Based on a lipid profile with triglycerides at 190 mg/dL, cholesterol at 225 mg/dL, and HDL at 75 mg/dL, what is the calculated LDL cholesterol?

To calculate the LDL cholesterol, the most commonly used formula is the Friedewald equation:

LDL = Total cholesterol - HDL - (Triglycerides / 5)

This equation holds true under certain conditions, such as when triglyceride levels are below 400 mg/dL, which they are in this case at 190 mg/dL.

First, we substitute the given values into the formula:

• Total cholesterol = 225 mg/dL

• HDL = 75 mg/dL

• Triglycerides = 190 mg/dL

Now, we can plug in the values:

LDL = 225 - 75 - (190 / 5)

Next, we calculate the triglycerides part:

• 190 / 5 = 38

Now we can rewrite the equation:

LDL = 225 - 75 - 38

Finally, compute the results:

LDL = 225 - 75 = 150

Then, 150 - 38 = 112 mg/dL.

The correct calculated LDL cholesterol is 112 mg/dL, which corresponds to the first option. This calculation is a standard approach in clinical settings when interpreting lipid profiles, allowing healthcare professionals to assess cardiovascular risk.